SAR7334 hydrochloride( —— )

Catalog No. M33118 CAS No. 1333207-63-8

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Datasheet

HNMR

HPLC

MSDS

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Product Name

SAR7334 hydrochloride
Note

Research use only, not for human use.
Brief Description

SAR7334 hydrochloride, a potent and specific inhibitor of TRPC6 (IC50 of 7.9 nM), effectively targets and inhibits the TRPC6 channel.
Description

SAR7334 hydrochloride is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.
In Vitro

SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca2+ influx into cells with IC50s of 9.5, 282 and 226?nM, whereas TRPC4 and TRPC5-mediated Ca2+ entry is not affected. SAR7334 (1?μM) results in a major block of the Ang II-evoked calcium influx in the podocytes. SAR7334 (1 μM) has negligible effect on SOCE. SAR7334 dose-dependently reduces TRPC6 currents with an IC50 of 7.9?nM. SAR7334 (100?nM) substantially reduces TRPC6 currents.
In Vivo

SAR7334 (10?mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR).
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

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Indication

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CAS Number

1333207-63-8
Formula Weight

440.79
Molecular Formula

C21H24Cl3N3O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (226.87 mM; Ultrasonic ) H2O : 50 mg/mL (113.43 mM; Ultrasonic)
SMILES

Cl.Cl.N[C@@H]1CCCN(C1)[C@@H]1Cc2ccccc2[C@H]1Oc1ccc(cc1Cl)C#N
Chemical Name

——

1. Ilatovskaya DV, et al. The Role of Angiotensin II in Glomerular Volume Dynamics and Podocyte Calcium Handling. Sci Rep. 2017 Mar 22;7(1):299.?

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